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Manuel B Graeber Publications in PubMed

1: Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I,
Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S,
Blurton-Jones M, Boddeke E, Brites D, Brône B, Brown GC, Butovsky O, Carson MJ,
Castellano B, Colonna M, Cowley SA, Cunningham C, Davalos D, De Jager PL, de
Strooper B, Denes A, Eggen BJL, Eyo U, Galea E, Garel S, Ginhoux F, Glass CK,
Gokce O, Gomez-Nicola D, González B, Gordon S, Graeber Manuel B, Greenhalgh AD,
Gressens P, Greter M, Gutmann DH, Haass C, Heneka MT, Heppner FL, Hong S, Hume
DA, Jung S, Kettenmann H, Kipnis J, Koyama R, Lemke G, Lynch M, Majewska A,
Malcangio M, Malm T, Mancuso R, Masuda T, Matteoli M, McColl BW, Miron VE,
Molofsky AV, Monje M, Mracsko E, Nadjar A, Neher JJ, Neniskyte U, Neumann H,
Noda M, Peng B, Peri F, Perry VH, Popovich PG, Pridans C, Priller J, Prinz M,
Ragozzino D, Ransohoff RM, Salter MW, Schaefer A, Schafer DP, Schwartz M, Simons
M, Smith CJ, Streit WJ, Tay TL, Tsai LH, Verkhratsky A, von Bernhardi R, Wake H,
Wittamer V, Wolf SA, Wu LJ, Wyss-Coray T. Microglia states and nomenclature: A
field at its crossroads. Neuron. 2022 Nov 2;110(21):3458-3483. doi:
10.1016/j.neuron.2022.10.020. PMID: 36327895; PMCID: PMC9999291.

2: Galea E, Graeber Manuel B. Neuroinflammation: The Abused Concept. ASN Neuro. 2023
Jan-Dec;15:17590914231197523. doi: 10.1177/17590914231197523. PMID: 37647500;
PMCID: PMC10469255.

3: Paasila PJ, Aramideh JA, Sutherland GT, Graeber Manuel B. Synapses, Microglia, and
Lipids in Alzheimer’s Disease. Front Neurosci. 2022 Jan 12;15:778822. doi:
10.3389/fnins.2021.778822. PMID: 35095394; PMCID: PMC8789683.

4: Müller U, Auburger G, Graeber Manuel B, Ptacek LJ. Developing the field of
neurogenetics. Neurogenetics. 2017 Dec;18(4):183-184. doi:
10.1007/s10048-017-0530-8. PMID: 29164503.

5: Vidal-Itriago A, Radford RAW, Aramideh JA, Maurel C, Scherer NM, Don EK, Lee
A, Chung RS, Graeber Manuel B, Morsch M. Microglia morphophysiological diversity and
its implications for the CNS. Front Immunol. 2022 Oct 19;13:997786. doi:
10.3389/fimmu.2022.997786. PMID: 36341385; PMCID: PMC9627549.

6: Auburger G, Graeber Manuel B, Ptáček LJ. Welcoming articles on genotype-dependent
clinical features and diagnostics. Neurogenetics. 2021 May;22(2):103-104. doi:
10.1007/s10048-021-00638-5. PMID: 33792798; PMCID: PMC8119393.

7: Aramideh JA, Vidal-Itriago A, Morsch M, Graeber Manuel B. Cytokine Signalling at
the Microglial Penta-Partite Synapse. Int J Mol Sci. 2021 Dec 7;22(24):13186.
doi: 10.3390/ijms222413186. PMID: 34947983; PMCID: PMC8708012.

8: Zheng Y, Graeber Manuel B. Microglia and Brain Macrophages as Drivers of Glioma
Progression. Int J Mol Sci. 2022 Dec 9;23(24):15612. doi: 10.3390/ijms232415612.
PMID: 36555253; PMCID: PMC9779147.

9: Graeber Manuel B. Changing face of microglia. Science. 2010 Nov 5;330(6005):783-8.
doi: 10.1126/science.1190929. PMID: 21051630.

10: Graeber Manuel B, Li W, Rodriguez ML. Role of microglia in CNS inflammation. FEBS
Lett. 2011 Dec 1;585(23):3798-805. doi: 10.1016/j.febslet.2011.08.033. Epub 2011
Aug 30. PMID: 21889505.

11: Graeber Manuel B, Streit WJ. Microglia: biology and pathology. Acta Neuropathol.
2010 Jan;119(1):89-105. doi: 10.1007/s00401-009-0622-0. Epub 2009 Dec 13. PMID:
20012873.

12: Alzoubi I, Bao G, Zheng Y, Wang X, Graeber Manuel B. Artificial intelligence
techniques for neuropathological diagnostics and research. Neuropathology. 2023
Aug;43(4):277-296. doi: 10.1111/neup.12880. Epub 2022 Nov 28. PMID: 36443935.

13: Graeber Manuel B. Biomarkers for Parkinson’s disease. Exp Neurol. 2009
Apr;216(2):249-53. doi: 10.1016/j.expneurol.2008.12.017. Epub 2009 Jan 7. PMID:
19166835.

14: Li W, Graeber Manuel B. The molecular profile of microglia under the influence of
glioma. Neuro Oncol. 2012 Aug;14(8):958-78. doi: 10.1093/neuonc/nos116. Epub
2012 May 9. PMID: 22573310; PMCID: PMC3408253.

15: Paradise MB, Naismith SL, Norrie LM, Graeber Manuel B, Hickie IB. The role of glia
in late-life depression. Int Psychogeriatr. 2012 Dec;24(12):1878-90. doi:
10.1017/S1041610212000828. Epub 2012 Jul 3. PMID: 22874475.

16: Graeber Manuel B, Streit WJ. Microglia: immune network in the CNS. Brain Pathol.
1990 Sep;1(1):2-5. doi: 10.1111/j.1750-3639.1990.tb00630.x. PMID: 1669689.

17: Graeber Manuel B, Mehraein P. Microglial rod cells. Neuropathol Appl Neurobiol.
1994 Apr;20(2):178-80. PMID: 8072649.

18: Graeber Manuel B, Streit WJ. Perivascular microglia defined. Trends Neurosci. 1990
Sep;13(9):366. doi: 10.1016/0166-2236(90)90020-B. PMID: 1699325.

19: Graeber Manuel B, Scheithauer BW, Kreutzberg GW. Microglia in brain tumors. Glia.
2002 Nov;40(2):252-259. doi: 10.1002/glia.10147. PMID: 12379912.

20: Hallal S, Ebrahimkhani S, Shivalingam B, Graeber Manuel B, Kaufman KL, Buckland
ME. The emerging clinical potential of circulating extracellular vesicles for
non-invasive glioma diagnosis and disease monitoring. Brain Tumor Pathol. 2019
Apr;36(2):29-39. doi: 10.1007/s10014-019-00335-0. Epub 2019 Mar 11. PMID:
30859343.

21: Moran LB, Graeber Manuel B. The facial nerve axotomy model. Brain Res Brain Res
Rev. 2004 Mar;44(2-3):154-78. doi: 10.1016/j.brainresrev.2003.11.004. PMID:
15003391.

22: Li W, Holsinger RM, Kruse CA, Flügel A, Graeber Manuel B. The potential for
genetically altered microglia to influence glioma treatment. CNS Neurol Disord
Drug Targets. 2013 Sep;12(6):750-62. doi: 10.2174/18715273113126660171. PMID:
24047526; PMCID: PMC4030521.

23: Kösel S, Hofhaus G, Maassen A, Vieregge P, Graeber Manuel B. Role of mitochondria
in Parkinson disease. Biol Chem. 1999 Jul-Aug;380(7-8):865-70. doi:
10.1515/BC.1999.106. PMID: 10494835.

24: Streit WJ, Graeber Manuel B, Kreutzberg GW. Functional plasticity of microglia: a
review. Glia. 1988;1(5):301-7. doi: 10.1002/glia.440010502. PMID: 2976393.

25: Graeber Manuel B. Genetics of neuroinflammation in Alzheimer disease.
Neurogenetics. 1999 Sep;2(3):135-6. doi: 10.1007/s100480050073. PMID: 10541585.

26: Graeber Manuel B. Neuroinflammation: no rose by any other name. Brain Pathol. 2014
Nov;24(6):620-2. doi: 10.1111/bpa.12192. PMID: 25345892; PMCID: PMC8029225.

27: Graeber Manuel B. Twenty-first century brain banking: at the crossroads. Acta
Neuropathol. 2008 May;115(5):493-6. doi: 10.1007/s00401-008-0363-5. PMID:
18347804.

28: Graeber Manuel B, Christie MJ. Multiple mechanisms of microglia: a gatekeeper’s
contribution to pain states. Exp Neurol. 2012 Apr;234(2):255-61. doi:
10.1016/j.expneurol.2012.01.007. Epub 2012 Jan 16. PMID: 22273537.

29: Müller U, Graeber Manuel B, Haberhausen G, Köhler A. Molecular basis and diagnosis
of neurogenetic disorders. J Neurol Sci. 1994 Jul;124(2):119-40. doi:
10.1016/0022-510x(94)90318-2. PMID: 7964863.

30: Streit WJ, Graeber Manuel B. Microglia: a pictorial. Prog Histochem Cytochem.
1996;31(1):1-89. doi: 10.1016/s0079-6336(96)80004-0. PMID: 8893306.

31: Graeber Manuel B, Grasbon-Frodl E, Eitzen UV, Kösel S. Neurodegeneration and
aging: role of the second genome. J Neurosci Res. 1998 Apr 1;52(1):1-6. doi:
10.1002/(SICI)1097-4547(19980401)52:1<1::AID-JNR1>3.0.CO;2-I. PMID: 9556024.

32: Filiou MD, Banati RB, Graeber Manuel B. The 18-kDa Translocator Protein as a CNS
Drug Target: Finding Our Way Through the Neuroinflammation Fog. CNS Neurol
Disord Drug Targets. 2017;16(9):990-999. doi: 10.2174/1871527316666171004125107.
PMID: 28982340.

33: Graeber Manuel B, Müller U. Dementia with Lewy bodies: disease concept and
genetics. Neurogenetics. 2003 Aug;4(4):157-62. doi: 10.1007/s10048-003-0155-y.
Epub 2003 Jul 26. PMID: 12898286.

34: Muller U, Graeber Manuel B. Neurogenetic diseases: molecular diagnosis and
therapeutic approaches. J Mol Med (Berl). 1996 Feb;74(2):71-84. doi:
10.1007/BF00196782. PMID: 8820402.

35: Svahn AJ, Becker TS, Graeber Manuel B. Emergent properties of microglia. Brain
Pathol. 2014 Nov;24(6):665-70. doi: 10.1111/bpa.12195. PMID: 25345896; PMCID:
PMC8029137.

36: Graeber Manuel B, Müller U. The X-linked dystonia-parkinsonism syndrome (XDP):
clinical and molecular genetic analysis. Brain Pathol. 1992 Oct;2(4):287-95.
doi: 10.1111/j.1750-3639.1992.tb00706.x. PMID: 1364136.

37: Banati RB, Wilcox P, Xu R, Yin G, Si E, Son ET, Shimizu M, Holsinger RMD,
Parmar A, Zahra D, Arthur A, Middleton RJ, Liu GJ, Charil A, Graeber Manuel B.
Selective, high-contrast detection of syngeneic glioblastoma in vivo. Sci Rep.
2020 Jun 19;10(1):9968. doi: 10.1038/s41598-020-67036-z. Erratum in: Sci Rep.
2020 Sep 24;10(1):16011. PMID: 32561881; PMCID: PMC7305160.

38: Banati RB, Graeber Manuel B. Surveillance, intervention and cytotoxicity: is there
a protective role of microglia? Dev Neurosci. 1994;16(3-4):114-27. doi:
10.1159/000112098. PMID: 7705219.

39: Graeber Manuel B, Moran LB. Mechanisms of cell death in neurodegenerative
diseases: fashion, fiction, and facts. Brain Pathol. 2002 Jul;12(3):385-90. doi:
10.1111/j.1750-3639.2002.tb00452.x. Erratum in: Brain Pathol. 2002 Oct;
12(4):522. PMID: 12146806; PMCID: PMC8095773.

40: Graeber Manuel B, Müller U. Recent developments in the molecular genetics of
mitochondrial disorders. J Neurol Sci. 1998 Jan 8;153(2):251-63. doi:
10.1016/s0022-510x(97)00295-5. PMID: 9511882.

41: Malaspina A, Pearce RK, Graeber Manuel B. Nuclear hormone and orphan receptors:
their role in neuronal differentiation and cytoprotection and in the
pathogenesis of Parkinson’s disease. Dev Neurosci. 2003 Nov-Dec;25(6):375-83.
doi: 10.1159/000075663. PMID: 14966378.

42: Croisier E, Graeber Manuel B. Glial degeneration and reactive gliosis in alpha-
synucleinopathies: the emerging concept of primary gliodegeneration. Acta
Neuropathol. 2006 Nov;112(5):517-30. doi: 10.1007/s00401-006-0119-z. Epub 2006
Aug 1. PMID: 16896905.

43: Streit WJ, Graeber Manuel B. Heterogeneity of microglial and perivascular cell
populations: insights gained from the facial nucleus paradigm. Glia. 1993
Jan;7(1):68-74. doi: 10.1002/glia.440070112. PMID: 8423064.

44: Graeber Manuel B, Dexter D, Pearce RK, Reynolds R. Parkinson’s disease: an update.
Neuropathol Appl Neurobiol. 2003 Oct;29(5):514-5. doi:
10.1046/j.1365-2990.2003.00461.x. PMID: 14507344.

45: Paasila PJ, Fok SYY, Flores-Rodriguez N, Sajjan S, Svahn AJ, Dennis CV,
Holsinger RMD, Kril JJ, Becker TS, Banati RB, Sutherland GT, Graeber Manuel B. Ground
state depletion microscopy as a tool for studying microglia-synapse
interactions. J Neurosci Res. 2021 Jun;99(6):1515-1532. doi: 10.1002/jnr.24819.
Epub 2021 Mar 7. PMID: 33682204; PMCID: PMC8251743.

46: AlShakweer W, Alwelaie Y, Mankung AM, Graeber Manuel B. Bone marrow-derived
microglia in pilocytic astrocytoma. Front Biosci (Elite Ed). 2011 Jan
1;3(1):371-9. doi: 10.2741/e252. PMID: 21196317.

47: Banati RB, Wilcox P, Xu R, Yin G, Si E, Son ET, Shimizu M, Holsinger RMD,
Parmar A, Zahra D, Arthur A, Middleton RJ, Liu GJ, Charil A, Graeber Manuel B. Author
Correction: Selective, high-contrast detection of syngeneic glioblastoma in
vivo. Sci Rep. 2020 Sep 24;10(1):16011. doi: 10.1038/s41598-020-72364-1. Erratum
for: Sci Rep. 2020 Jun 19;10(1):9968. PMID: 32968119; PMCID: PMC7511297.

48: Geranmayeh F, Scheithauer BW, Spitzer C, Meyer FB, Svensson-Engwall AC,
Graeber Manuel B. Microglia in gemistocytic astrocytomas. Neurosurgery. 2007
Jan;60(1):159-66; discussion 166. doi: 10.1227/01.NEU.0000249192.30786.67. PMID:
17228265.

49: Kösel S, Grasbon-Frodl EM, Graeber Manuel B. A new approach to the genetic
analysis of nervous system diseases: retrospective genotyping of archival
brains. Prog Brain Res. 1998;117:307-13. doi: 10.1016/s0079-6123(08)64023-6.
PMID: 9932416.

50: Alzoubi I, Bao G, Zhang R, Loh C, Zheng Y, Cherepanoff S, Gracie G, Lee M,
Kuligowski M, Alexander KL, Buckland ME, Wang X, Graeber Manuel B. An Open-Source AI
Framework for the Analysis of Single Cells in Whole-Slide Images with a Note on
CD276 in Glioblastoma. Cancers (Basel). 2022 Jul 15;14(14):3441. doi:
10.3390/cancers14143441. PMID: 35884502; PMCID: PMC9316952.

51: Gedye C, Sachchithananthan M, Leonard R, Jeffree RL, Buckland ME, Ziegler
DS, Graeber Manuel B, Day BW, McDonald KL, Lasocki A; BCBA Consortium; Nowak AK.
Driving innovation through collaboration: development of clinical annotation
datasets for brain cancer biobanking. Neurooncol Pract. 2020 Jan;7(1):31-37.
doi: 10.1093/nop/npz036. Epub 2019 Aug 27. PMID: 32257282; PMCID: PMC7104879.

52: Buljan VA, Graeber Manuel B, Holsinger RMD, Brown D, Hambly BD, Delikatny EJ,
Vuletic VR, Krebs XN, Tomas IB, Bohorquez-Florez JJ, Liu GJ, Banati RB. Calcium-
axonemal microtubuli interactions underlie mechanism(s) of primary cilia
morphological changes. J Biol Phys. 2018 Mar;44(1):53-80. doi:
10.1007/s10867-017-9475-2. Epub 2017 Oct 31. PMID: 29090363; PMCID: PMC5834999.

53: Svahn AJ, Giacomotto J, Graeber Manuel B, Rinkwitz S, Becker TS. miR-124
Contributes to the functional maturity of microglia. Dev Neurobiol. 2016
May;76(5):507-18. doi: 10.1002/dneu.22328. Epub 2015 Jul 25. PMID: 26184457.

54: Liu AKL, Chau TW, Lim EJ, Ahmed I, Chang RC, Kalaitzakis ME, Graeber Manuel B,
Gentleman SM, Pearce RKB. Hippocampal CA2 Lewy pathology is associated with
cholinergic degeneration in Parkinson’s disease with cognitive decline. Acta
Neuropathol Commun. 2019 Apr 25;7(1):61. doi: 10.1186/s40478-019-0717-3. PMID:
31023342; PMCID: PMC6485180.

55: Kreutzberg GW, Graeber Manuel B, Streit WJ. Neuron-glial relationship during
regeneration of motorneurons. Metab Brain Dis. 1989 Mar;4(1):81-5. doi:
10.1007/BF00999498. PMID: 2649780.

56: Bao G, Wang X, Xu R, Loh C, Adeyinka OD, Pieris DA, Cherepanoff S, Gracie G,
Lee M, McDonald KL, Nowak AK, Banati R, Buckland ME, Graeber Manuel B. PathoFusion: An
Open-Source AI Framework for Recognition of Pathomorphological Features and
Mapping of Immunohistochemical Data. Cancers (Basel). 2021 Feb 4;13(4):617. doi:
10.3390/cancers13040617. PMID: 33557152; PMCID: PMC7913958.

57: Kösel S, Scheithauer BW, Graeber Manuel B. Genotype-phenotype correlation in
gemistocytic astrocytomas. Neurosurgery. 2001 Jan;48(1):187-93; discussion
193-4. doi: 10.1097/00006123-200101000-00033. PMID: 11152345.

58: Wang D, Liu C, Wang X, Liu X, Lan C, Zhao P, Cho WC, Graeber Manuel B, Liu Y.
Automated Machine-Learning Framework Integrating Histopathological and
Radiological Information for Predicting IDH1 Mutation Status in Glioma. Front
Bioinform. 2021 Oct 26;1:718697. doi: 10.3389/fbinf.2021.718697. PMID: 36303770;
PMCID: PMC9581043.

59: Graeber Manuel B, Streit WJ, Kreutzberg GW. The third glial cell type, the
microglia: cellular markers of activation in situ. Acta Histochem Suppl.
1990;38:157-60. PMID: 2080239.

60: Graeber Manuel B, Banati RB, Flügel A, Streit WJ, Tetzlaff W. Courage, luck and
patience: in celebration of the 80th birthday of Georg W. Kreutzberg. Acta
Neuropathol. 2012 Oct;124(4):593-8. doi: 10.1007/s00401-012-1033-1. Epub 2012
Aug 12. PMID: 22886135.

61: Banati RB, Egensperger R, Maassen A, Hager G, Kreutzberg GW, Graeber Manuel B.
Mitochondria in activated microglia in vitro. J Neurocytol. 2004
Sep;33(5):535-41. doi: 10.1007/s11068-004-0515-7. PMID: 15906160.

62: Michael GJ, Esmailzadeh S, Moran LB, Christian L, Pearce RK, Graeber Manuel B. Up-
regulation of metallothionein gene expression in parkinsonian astrocytes.
Neurogenetics. 2011 Nov;12(4):295-305. doi: 10.1007/s10048-011-0294-5. Epub 2011
Jul 29. PMID: 21800131.

63: Duke DC, Moran LB, Turkheimer FE, Banati R, Graeber Manuel B. Microglia in
culture: what genes do they express? Dev Neurosci. 2004 Jan-Feb;26(1):30-7. doi:
10.1159/000080709. PMID: 15509896.

64: Duffy SL, Lagopoulos J, Hickie IB, Diamond K, Graeber Manuel B, Lewis SJ, Naismith
SL. Glutathione relates to neuropsychological functioning in mild cognitive
impairment. Alzheimers Dement. 2014 Jan;10(1):67-75. doi:
10.1016/j.jalz.2013.01.005. Epub 2013 May 18. PMID: 23688577.

65: Banati RB, Middleton RJ, Chan R, Hatty CR, Kam WW, Quin C, Graeber Manuel B,
Parmar A, Zahra D, Callaghan P, Fok S, Howell NR, Gregoire M, Szabo A, Pham T,
Davis E, Liu GJ. Positron emission tomography and functional characterization of
a complete PBR/TSPO knockout. Nat Commun. 2014 Nov 19;5:5452. doi:
10.1038/ncomms6452. PMID: 25406832; PMCID: PMC4263137.

66: Svahn AJ, Don EK, Badrock AP, Cole NJ, Graeber Manuel B, Yerbury JJ, Chung R,
Morsch M. Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired
microglia function leads to axonal spreading of TDP-43 in degenerating motor
neurons. Acta Neuropathol. 2018 Sep;136(3):445-459. doi:
10.1007/s00401-018-1875-2. Epub 2018 Jun 25. PMID: 29943193; PMCID: PMC6096729.

67: Moran LB, Duke DC, Turkheimer FE, Banati RB, Graeber Manuel B. Towards a
transcriptome definition of microglial cells. Neurogenetics. 2004
Jun;5(2):95-108. doi: 10.1007/s10048-004-0172-5. Epub 2004 Mar 20. PMID:
15042428.

68: Dennis CV, Sheahan PJ, Graeber Manuel B, Sheedy DL, Kril JJ, Sutherland GT.
Microglial proliferation in the brain of chronic alcoholics with hepatic
encephalopathy. Metab Brain Dis. 2014 Dec;29(4):1027-39. doi:
10.1007/s11011-013-9469-0. Epub 2013 Dec 19. PMID: 24346482; PMCID: PMC4063896.

69: Kösel S, Egensperger R, von Eitzen U, Mehraein P, Graeber Manuel B. On the
question of apoptosis in the parkinsonian substantia nigra. Acta Neuropathol.
1997 Feb;93(2):105-8. doi: 10.1007/s004010050590. PMID: 9039456.

70: Achim C, Auer R, Bergeron C, Cardozo A, Deprez M, de Vos R, Duyckaerts C,
Egensperger R, Esiri M, Frosch MP, Giannini C, Goebel HH, Graeber Manuel B, Graham DI,
Gray F, Haltia M, Hashizume Y, Ikeda K, Ironside JW, Kreutzberg GW, Lantos P,
Lowe J, Ludwin S, Matsumoto Y, Olsson Y, Sasaki A, Scheithauer BW, Takahashi H,
Tolnay M, Trojanowski JQ, Troost D, de F Webster H. Global democratic consensus
on neuropathological disease criteria. Lancet Neurol. 2002 Oct;1(6):340. doi:
10.1016/s1474-4422(02)00156-4. PMID: 12849392.

71: Graeber Manuel B, Kreutzberg GW. Delayed astrocyte reaction following facial nerve
axotomy. J Neurocytol. 1988 Apr;17(2):209-20. doi: 10.1007/BF01674208. PMID:
2849645.

72: Croisier E, MRes DE, Deprez M, Goldring K, Dexter DT, Pearce RK, Graeber Manuel B,
Roncaroli F. Comparative study of commercially available anti-alpha-synuclein
antibodies. Neuropathol Appl Neurobiol. 2006 Jun;32(3):351-6. doi:
10.1111/j.1365-2990.2006.00722.x. PMID: 16640654.

73: Kalaitzakis ME, Graeber Manuel B, Gentleman SM, Pearce RK. Striatal beta-amyloid
deposition in Parkinson disease with dementia. J Neuropathol Exp Neurol. 2008
Feb;67(2):155-61. doi: 10.1097/NEN.0b013e31816362aa. PMID: 18219254.

74: Sajjan S, Holsinger RM, Fok S, Ebrahimkhani S, Rollo JL, Banati RB, Graeber
MB. Up-regulation of matrix metallopeptidase 12 in motor neurons undergoing
synaptic stripping. Neuroscience. 2014 Aug 22;274:331-40. doi:
10.1016/j.neuroscience.2014.05.052. Epub 2014 Jun 4. PMID: 24907602.

75: Svahn AJ, Graeber Manuel B, Ellett F, Lieschke GJ, Rinkwitz S, Bennett MR, Becker
TS. Development of ramified microglia from early macrophages in the zebrafish
optic tectum. Dev Neurobiol. 2013 Jan;73(1):60-71. doi: 10.1002/dneu.22039. Epub
2012 Jul 20. PMID: 22648905.

76: Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC,
Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P,
Miller RM, Federoff HJ, Wüllner U, Papapetropoulos S, Youdim MB, Cantuti-
Castelvetri I, Young AB, Vance JM, Davis RL, Hedreen JC, Adler CH, Beach TG,
Graeber Manuel B, Middleton FA, Rochet JC, Scherzer CR; Global PD Gene Expression
(GPEX) Consortium. PGC-1α, a potential therapeutic target for early intervention
in Parkinson’s disease. Sci Transl Med. 2010 Oct 6;2(52):52ra73. doi:
10.1126/scitranslmed.3001059. PMID: 20926834; PMCID: PMC3129986.

77: Kalaitzakis ME, Graeber Manuel B, Gentleman SM, Pearce RK. Parkinson disease:
extranigral, multisystem, and {alpha}-synuclein “plus”. Arch Neurol. 2009
Jul;66(7):914-5; author reply 915-6. doi: 10.1001/archneurol.2009.140. PMID:
19597100.

78: Kupke KG, Graeber Manuel B, Müller U. Dystonia-parkinsonism syndrome (XDP) locus:
flanking markers in Xq12-q21.1. Am J Hum Genet. 1992 Apr;50(4):808-15. PMID:
1550125; PMCID: PMC1682654.

79: Graeber Manuel B, Kupke KG, Müller U. Delineation of the dystonia-parkinsonism
syndrome locus in Xq13. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8245-8. doi:
10.1073/pnas.89.17.8245. PMID: 1518853; PMCID: PMC49894.

80: Kalaitzakis ME, Graeber Manuel B, Gentleman SM, Pearce RK. Controversies over the
staging of alpha-synuclein pathology in Parkinson’s disease. Acta Neuropathol.
2008 Jul;116(1):125-8; author reply 129-31. doi: 10.1007/s00401-008-0381-3. Epub
2008 Apr 30. PMID: 18446352.

81: Graeber Manuel B, Mehraein P. Reanalysis of the first case of Alzheimer’s disease.
Eur Arch Psychiatry Clin Neurosci. 1999;249 Suppl 3:10-3. doi:
10.1007/pl00014167. PMID: 10654094.

82: Graeber Manuel B, Streit WJ, Kreutzberg GW. Identity of ED2-positive perivascular
cells in rat brain. J Neurosci Res. 1989 Jan;22(1):103-6. doi:
10.1002/jnr.490220114. PMID: 2926837.

83: Müller U, Winter P, Graeber Manuel B. A presenilin 1 mutation in the first case of
Alzheimer’s disease. Lancet Neurol. 2013 Feb;12(2):129-30. doi:
10.1016/S1474-4422(12)70307-1. Epub 2012 Dec 14. PMID: 23246540.

84: Filiou MD, Arefin AS, Moscato P, Graeber Manuel B. ‘Neuroinflammation’ differs
categorically from inflammation: transcriptomes of Alzheimer’s disease,
Parkinson’s disease, schizophrenia and inflammatory diseases compared.
Neurogenetics. 2014 Aug;15(3):201-12. doi: 10.1007/s10048-014-0409-x. Epub 2014
Jun 15. PMID: 24928144.

85: Lücking CB, Kösel S, Mehraein P, Graeber Manuel B. Absence of the mitochondrial
A7237T mutation in Parkinson’s disease. Biochem Biophys Res Commun. 1995 Jun
15;211(2):700-4. doi: 10.1006/bbrc.1995.1868. PMID: 7794285.

86: Markiewicz S, DiSanto JP, Chelly J, Fairweather N, Le Marec B, Griscelli C,
Graeber Manuel B, Müller U, Fischer A, Monaco AP, et al. Fine mapping of the human
SCIDX1 locus at Xq12-13.1. Hum Mol Genet. 1993 Jun;2(6):651-4. doi:
10.1093/hmg/2.6.651. PMID: 8353486.

87: Alafuzoff I, Arzberger T, Al-Sarraj S, Bodi I, Bogdanovic N, Braak H,
Bugiani O, Del-Tredici K, Ferrer I, Gelpi E, Giaccone G, Graeber Manuel B, Ince P,
Kamphorst W, King A, Korkolopoulou P, Kovács GG, Larionov S, Meyronet D,
Monoranu C, Parchi P, Patsouris E, Roggendorf W, Seilhean D, Tagliavini F,
Stadelmann C, Streichenberger N, Thal DR, Wharton SB, Kretzschmar H. Staging of
neurofibrillary pathology in Alzheimer’s disease: a study of the BrainNet Europe
Consortium. Brain Pathol. 2008 Oct;18(4):484-96. doi:
10.1111/j.1750-3639.2008.00147.x. Epub 2008 Mar 26. PMID: 18371174; PMCID:
PMC2659377.

88: Schnopp NM, Kösel S, Egensperger R, Graeber Manuel B. Regional heterogeneity of
mtDNA heteroplasmy in parkinsonian brain. Clin Neuropathol. 1996 Nov-
Dec;15(6):348-52. PMID: 8937782.

89: Moran LB, Duke DC, Graeber Manuel B. The microglial gene regulatory network
activated by interferon-gamma. J Neuroimmunol. 2007 Feb;183(1-2):1-6. doi:
10.1016/j.jneuroim.2006.10.023. Epub 2006 Dec 22. PMID: 17188367.

90: Kalaitzakis ME, Graeber Manuel B, Gentleman SM, Pearce RK. Evidence against a
reliable staging system of alpha-synuclein pathology in Parkinson’s disease.
Neuropathol Appl Neurobiol. 2009 Feb;35(1):125-6. doi:
10.1111/j.1365-2990.2008.00998.x. PMID: 19187066.

91: Durrenberger PF, Filiou MD, Moran LB, Michael GJ, Novoselov S, Cheetham ME,
Clark P, Pearce RK, Graeber Manuel B. DnaJB6 is present in the core of Lewy bodies and
is highly up-regulated in parkinsonian astrocytes. J Neurosci Res. 2009
Jan;87(1):238-45. doi: 10.1002/jnr.21819. PMID: 18711724.

92: Graeber Manuel B, Bise K, Mehraein P. CR3/43, a marker for activated human
microglia: application to diagnostic neuropathology. Neuropathol Appl Neurobiol.
1994 Aug;20(4):406-8. doi: 10.1111/j.1365-2990.1994.tb00987.x. PMID: 7808591.

93: Kalaitzakis ME, Christian LM, Moran LB, Graeber Manuel B, Pearce RK, Gentleman SM.
Dementia and visual hallucinations associated with limbic pathology in
Parkinson’s disease. Parkinsonism Relat Disord. 2009 Mar;15(3):196-204. doi:
10.1016/j.parkreldis.2008.05.007. Epub 2008 Jul 7. PMID: 18602855.

94: Kösel S, Egensperger R, Mehraein P, Graeber Manuel B. No association of mutations
at nucleotide 5460 of mitochondrial NADH dehydrogenase with Alzheimer’s disease.
Biochem Biophys Res Commun. 1994 Sep 15;203(2):745-9. doi:
10.1006/bbrc.1994.2245. PMID: 8093052.

95: Flügel A, Hager G, Horvat A, Spitzer C, Singer GM, Graeber Manuel B, Kreutzberg
GW, Schwaiger FW. Neuronal MCP-1 expression in response to remote nerve injury.
J Cereb Blood Flow Metab. 2001 Jan;21(1):69-76. doi:
10.1097/00004647-200101000-00009. PMID: 11149670.

96: Kösel S, Grasbon-Frodl EM, Hagenah JM, Graeber Manuel B, Vieregge P. Parkinson
disease: analysis of mitochondrial DNA in monozygotic twins. Neurogenetics. 2000
Mar;2(4):227-30. doi: 10.1007/pl00022973. PMID: 10983718.

97: von Eitzen U, Kösel S, Grasbon-Frodl EM, Egensperger R, Graeber Manuel B. Sequence
analysis of the MTCYB gene in Parkinson disease. Neurogenetics. 2000
Sep;3(1):47-8. doi: 10.1007/pl00022980. PMID: 11085598.

98: Moran LB, Duke DC, Deprez M, Dexter DT, Pearce RK, Graeber Manuel B. Whole genome
expression profiling of the medial and lateral substantia nigra in Parkinson’s
disease. Neurogenetics. 2006 Mar;7(1):1-11. doi: 10.1007/s10048-005-0020-2. Epub
2006 Jan 12. PMID: 16344956.

99: Kösel S, Lücking CB, Egensperger R, Mehraein P, Graeber Manuel B. Mitochondrial
NADH dehydrogenase and CYP2D6 genotypes in Lewy-body parkinsonism. J Neurosci
Res. 1996 Apr 15;44(2):174-83. doi:
10.1002/(SICI)1097-4547(19960415)44:2<174::AID-JNR10>3.0.CO;2-6. PMID: 8723226.

100: Egensperger R, Bancher C, Kösel S, Jellinger K, Mehraein P, Graeber Manuel B. The
apolipoprotein E epsilon 4 allele in Parkinson’s disease with Alzheimer lesions.
Biochem Biophys Res Commun. 1996 Jul 16;224(2):484-6. doi:
10.1006/bbrc.1996.1053. PMID: 8702415.

101: Egensperger R, Kösel S, von Eitzen U, Graeber Manuel B. Microglial activation in
Alzheimer disease: Association with APOE genotype. Brain Pathol. 1998
Jul;8(3):439-47. doi: 10.1111/j.1750-3639.1998.tb00166.x. PMID: 9669695; PMCID:
PMC8098510.

102: Moran LB, Hickey L, Michael GJ, Derkacs M, Christian LM, Kalaitzakis ME,
Pearce RK, Graeber Manuel B. Neuronal pentraxin II is highly upregulated in
Parkinson’s disease and a novel component of Lewy bodies. Acta Neuropathol. 2008
Apr;115(4):471-8. doi: 10.1007/s00401-007-0309-3. Epub 2007 Nov 7. PMID:
17987278; PMCID: PMC2270353.

103: Graeber Manuel B, Streit WJ, Kreutzberg GW. The microglial cytoskeleton: vimentin
is localized within activated cells in situ. J Neurocytol. 1988
Aug;17(4):573-80. doi: 10.1007/BF01189811. PMID: 3193132.

104: Graeber Manuel B. No man alone: the rediscovery of Alois Alzheimer’s original
cases. Brain Pathol. 1999 Apr;9(2):237-40. doi:
10.1111/j.1750-3639.1999.tb00221.x. Erratum in: Brain Pathol 1999 Oct;9(4):755.
PMID: 10219740; PMCID: PMC8098424.

105: Nakajima K, Graeber Manuel B, Sonoda M, Tohyama Y, Kohsaka S, Kurihara T. In
vitro proliferation of axotomized rat facial nucleus-derived activated microglia
in an autocrine fashion. J Neurosci Res. 2006 Aug 1;84(2):348-59. doi:
10.1002/jnr.20882. PMID: 16673407.

106: Flügel A, Schwaiger FW, Neumann H, Medana I, Willem M, Wekerle H,
Kreutzberg GW, Graeber Manuel B. Neuronal FasL induces cell death of encephalitogenic
T lymphocytes. Brain Pathol. 2000 Jul;10(3):353-64. doi:
10.1111/j.1750-3639.2000.tb00267.x. PMID: 10885654; PMCID: PMC8098261.

107: Jones LL, Banati RB, Graeber Manuel B, Bonfanti L, Raivich G, Kreutzberg GW.
Population control of microglia: does apoptosis play a role? J Neurocytol. 1997
Nov;26(11):755-70. doi: 10.1023/a:1018514415073. PMID: 9426172.

108: Graeber Manuel B, Tetzlaff W, Streit WJ, Kreutzberg GW. Microglial cells but not
astrocytes undergo mitosis following rat facial nerve axotomy. Neurosci Lett.
1988 Mar 10;85(3):317-21. doi: 10.1016/0304-3940(88)90585-x. PMID: 3362421.

109: Kösel S, Grasbon-Frodl EM, Mautsch U, Egensperger R, von Eitzen U, Frishman
D, Hofmann S, Gerbitz KD, Mehraein P, Graeber Manuel B. Novel mutations of
mitochondrial complex I in pathologically proven Parkinson disease.
Neurogenetics. 1998 Mar;1(3):197-204. doi: 10.1007/s100480050029. PMID:
10737123.

110: Moran LB, Croisier E, Duke DC, Kalaitzakis ME, Roncaroli F, Deprez M,
Dexter DT, Pearce RK, Graeber Manuel B. Analysis of alpha-synuclein, dopamine and
parkin pathways in neuropathologically confirmed parkinsonian nigra. Acta
Neuropathol. 2007 Mar;113(3):253-63. doi: 10.1007/s00401-006-0181-6. Epub 2007
Jan 4. PMID: 17203291.

111: Duke DC, Moran LB, Kalaitzakis ME, Deprez M, Dexter DT, Pearce RK, Graeber
MB. Transcriptome analysis reveals link between proteasomal and mitochondrial
pathways in Parkinson’s disease. Neurogenetics. 2006 Jul;7(3):139-48. doi:
10.1007/s10048-006-0033-5. Epub 2006 May 13. PMID: 16699787.

112: Graeber Manuel B, López-Redondo F, Ikoma E, Ishikawa M, Imai Y, Nakajima K,
Kreutzberg GW, Kohsaka S. The microglia/macrophage response in the neonatal rat
facial nucleus following axotomy. Brain Res. 1998 Dec 7;813(2):241-53. doi:
10.1016/s0006-8993(98)00859-2. PMID: 9838143.

113: Egensperger R, Kösel S, Schnopp NM, Mehraein P, Graeber Manuel B. Association of
the mitochondrial tRNA(A4336G) mutation with Alzheimer’s and Parkinson’s
diseases. Neuropathol Appl Neurobiol. 1997 Aug;23(4):315-21. PMID: 9292870.

114: Kösel S, Egensperger R, Schnopp NM, Graeber Manuel B. The ‘common deletion’ is
not increased in parkinsonian substantia nigra as shown by competitive
polymerase chain reaction. Mov Disord. 1997 Sep;12(5):639-45. doi:
10.1002/mds.870120504. PMID: 9380043.

115: Grasbon-Frodl EM, Egensperger R, Kösel S, Krüger R, Riess O, Mehraein P,
Graeber Manuel B. The alpha1-antichymotrypsin A-allele in German Parkinson disease
patients. J Neural Transm (Vienna). 1999;106(7-8):729-36. doi:
10.1007/s007020050193. PMID: 10907731.

116: Moss J, Ryder T, Aziz TZ, Graeber Manuel B, Bain PG. Electron microscopy of
tissue adherent to explanted electrodes in dystonia and Parkinson’s disease.
Brain. 2004 Dec;127(Pt 12):2755-63. doi: 10.1093/brain/awh292. Epub 2004 Aug 25.
PMID: 15329356.

117: Flügel A, Labeur MS, Grasbon-Frodl EM, Kreutzberg GW, Graeber Manuel B. Microglia
only weakly present glioma antigen to cytotoxic T cells. Int J Dev Neurosci.
1999 Aug-Oct;17(5-6):547-56. doi: 10.1016/s0736-5748(99)00020-9. PMID: 10571416.

118: Alafuzoff I, Pikkarainen M, Al-Sarraj S, Arzberger T, Bell J, Bodi I,
Bogdanovic N, Budka H, Bugiani O, Ferrer I, Gelpi E, Giaccone G, Graeber Manuel B,
Hauw JJ, Kamphorst W, King A, Kopp N, Korkolopoulou P, Kovács GG, Meyronet D,
Parchi P, Patsouris E, Preusser M, Ravid R, Roggendorf W, Seilhean D,
Streichenberger N, Thal DR, Kretzschmar H. Interlaboratory comparison of
assessments of Alzheimer disease-related lesions: a study of the BrainNet Europe
Consortium. J Neuropathol Exp Neurol. 2006 Aug;65(8):740-57. doi:
10.1097/01.jnen.0000229986.17548.27. PMID: 16896308.

119: Grasbon-Frodl EM, Kösel S, Sprinzl M, von Eitzen U, Mehraein P, Graeber Manuel B.
Two novel point mutations of mitochondrial tRNA genes in histologically
confirmed Parkinson disease. Neurogenetics. 1999 Apr;2(2):121-7. doi:
10.1007/s100480050063. PMID: 10369889.

120: Graeber Manuel B, Grasbon-Frodl E, Abell-Aleff P, Kösel S. Nigral neurons are
likely to die of a mechanism other than classical apoptosis in Parkinson’s
disease. Parkinsonism Relat Disord. 1999 Dec;5(4):187-92. doi:
10.1016/s1353-8020(99)00036-x. PMID: 18591139.

121: Alafuzoff I, Pikkarainen M, Neumann M, Arzberger T, Al-Sarraj S, Bodi I,
Bogdanovic N, Bugiani O, Ferrer I, Gelpi E, Gentleman S, Giaccone G, Graeber Manuel B,
Hortobagyi T, Ince PG, Ironside JW, Kavantzas N, King A, Korkolopoulou P, Kovács
GG, Meyronet D, Monoranu C, Nilsson T, Parchi P, Patsouris E, Revesz T,
Roggendorf W, Rozemuller A, Seilhean D, Streichenberger N, Thal DR, Wharton SB,
Kretzschmar H. Neuropathological assessments of the pathology in frontotemporal
lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by
the BrainNet Europe consortium. J Neural Transm (Vienna). 2015
Jul;122(7):957-72. doi: 10.1007/s00702-014-1304-1. Epub 2014 Sep 20. Erratum in:
J Neural Transm (Vienna). 2015 Jul;122(7):973-4. PMID: 25239189.

122: Graeber Manuel B, Streit WJ, Büringer D, Sparks DL, Kreutzberg GW.
Ultrastructural location of major histocompatibility complex (MHC) class II
positive perivascular cells in histologically normal human brain. J Neuropathol
Exp Neurol. 1992 May;51(3):303-11. doi: 10.1097/00005072-199205000-00009. PMID:
1583535.

123: Graeber Manuel B, Raivich G, Kreutzberg GW. Increase of transferrin receptors and
iron uptake in regenerating motor neurons. J Neurosci Res. 1989 Jul;23(3):342-5.
doi: 10.1002/jnr.490230315. PMID: 2769797.

124: Graeber Manuel B, Streit WJ, Kiefer R, Schoen SW, Kreutzberg GW. New expression
of myelomonocytic antigens by microglia and perivascular cells following lethal
motor neuron injury. J Neuroimmunol. 1990 May;27(2-3):121-32. doi:
10.1016/0165-5728(90)90061-q. PMID: 2332482.

125: Graeber Manuel B, Kösel S, Egensperger R, Banati RB, Müller U, Bise K, Hoff P,
Möller HJ, Fujisawa K, Mehraein P. Rediscovery of the case described by Alois
Alzheimer in 1911: historical, histological and molecular genetic analysis.
Neurogenetics. 1997 May;1(1):73-80. doi: 10.1007/s100480050011. PMID: 10735278.

126: Kösel S, Graeber Manuel B. Use of neuropathological tissue for molecular genetic
studies: parameters affecting DNA extraction and polymerase chain reaction. Acta
Neuropathol. 1994;88(1):19-25. doi: 10.1007/BF00294355. PMID: 7941968.

127: Giannini C, Scheithauer BW, Weaver AL, Burger PC, Kros JM, Mork S, Graeber
MB, Bauserman S, Buckner JC, Burton J, Riepe R, Tazelaar HD, Nascimento AG,
Crotty T, Keeney GL, Pernicone P, Altermatt H. Oligodendrogliomas:
reproducibility and prognostic value of histologic diagnosis and grading. J
Neuropathol Exp Neurol. 2001 Mar;60(3):248-62. doi: 10.1093/jnen/60.3.248. PMID:
11245209.

128: Mathews A, Ohsawa K, Buckland ME, Kesavadas C, Ratheesan K, Kusumakumary P,
Burger PC, Kohsaka S, Graeber Manuel B. Microglioma in a child – a further case in
support of the microglioma entity and distinction from histiocytic sarcoma. Clin
Neuropathol. 2016 Sep-Oct;35(5):302-13. doi: 10.5414/NP300938. PMID: 27191913.

129: Müller U, Winter P, Graeber Manuel B. Alois Alzheimer’s case, Auguste D., did not
carry the N141I mutation in PSEN2 characteristic of Alzheimer disease in Volga
Germans. Arch Neurol. 2011 Sep;68(9):1210-1, author reply 1211. doi:
10.1001/archneurol.2011.218. PMID: 21911706.

130: v Eitzen U, Egensperger R, Kösel S, Grasbon-Frodl EM, Imai Y, Bise K,
Kohsaka S, Mehraein P, Graeber Manuel B. Microglia and the development of spongiform
change in Creutzfeldt-Jakob disease. J Neuropathol Exp Neurol. 1998
Mar;57(3):246-56. doi: 10.1097/00005072-199803000-00006. PMID: 9600217.

131: Alafuzoff I, Gelpi E, Al-Sarraj S, Arzberger T, Attems J, Bodi I,
Bogdanovic N, Budka H, Bugiani O, Englund E, Ferrer I, Gentleman S, Giaccone G,
Graeber Manuel B, Hortobagyi T, Höftberger R, Ironside JW, Jellinger K, Kavantzas N,
King A, Korkolopoulou P, Kovács GG, Meyronet D, Monoranu C, Parchi P, Patsouris
E, Roggendorf W, Rozemuller A, Seilhean D, Streichenberger N, Thal DR, Wharton
SB, Kretzschmar H. The need to unify neuropathological assessments of vascular
alterations in the ageing brain: multicentre survey by the BrainNet Europe
consortium. Exp Gerontol. 2012 Nov;47(11):825-33. doi:
10.1016/j.exger.2012.06.001. Epub 2012 Jun 15. PMID: 22705312.

132: Croisier E, Moran LB, Dexter DT, Pearce RK, Graeber Manuel B. Microglial
inflammation in the parkinsonian substantia nigra: relationship to alpha-
synuclein deposition. J Neuroinflammation. 2005 Jun 3;2:14. doi:
10.1186/1742-2094-2-14. PMID: 15935098; PMCID: PMC1177985.

133: Bancher C, Egensperger R, Kösel S, Jellinger K, Graeber Manuel B. Low prevalence
of apolipoprotein E epsilon 4 allele in the neurofibrillary tangle predominant
form of senile dementia. Acta Neuropathol. 1997 Nov;94(5):403-9. doi:
10.1007/s004010050726. PMID: 9386771.

134: Nacimiento W, Podoll K, Graeber Manuel B, Töpper R, Möbius E, Ostermann H, Noth
J, Kreutzberg GW. Contralateral early blink reflex in patients with facial nerve
palsy: indication for synaptic reorganization in the facial nucleus during
regeneration. J Neurol Sci. 1992 Jun;109(2):148-55. doi:
10.1016/0022-510x(92)90161-d. PMID: 1634897.

135: Graeber Manuel B, Kösel S, Grasbon-Frodl E, Möller HJ, Mehraein P. Histopathology
and APOE genotype of the first Alzheimer disease patient, Auguste D.
Neurogenetics. 1998 Mar;1(3):223-8. doi: 10.1007/s100480050033. PMID: 10737127.

136: Möller HJ, Graeber Manuel B. The case described by Alois Alzheimer in 1911.
Historical and conceptual perspectives based on the clinical record and
neurohistological sections. Eur Arch Psychiatry Clin Neurosci.
1998;248(3):111-22. doi: 10.1007/s004060050027. PMID: 9728729.

137: Slodzinski H, Moran LB, Michael GJ, Wang B, Novoselov S, Cheetham ME,
Pearce RK, Graeber Manuel B. Homocysteine-induced endoplasmic reticulum protein (herp)
is up-regulated in parkinsonian substantia nigra and present in the core of Lewy
bodies. Clin Neuropathol. 2009 Sep-Oct;28(5):333-43. PMID: 19788048.

138: Harris JE, Fernandez-Vilaseca M, Elkington PT, Horncastle DE, Graeber Manuel B,
Friedland JS. IFNgamma synergizes with IL-1beta to up-regulate MMP-9 secretion
in a cellular model of central nervous system tuberculosis. FASEB J. 2007
Feb;21(2):356-65. doi: 10.1096/fj.06-6925com. Epub 2006 Dec 11. PMID: 17158965.

139: Raivich G, Graeber Manuel B, Gehrmann J, Kreutzberg GW. Transferrin Receptor
Expression and Iron Uptake in the Injured and Regenerating Rat Sciatic Nerve.
Eur J Neurosci. 1991;3(10):919-927. doi: 10.1111/j.1460-9568.1991.tb00027.x.
PMID: 12106249.

140: Rieske E, Graeber Manuel B, Tetzlaff W, Czlonkowska A, Streit WJ, Kreutzberg GW.
Microglia and microglia-derived brain macrophages in culture: generation from
axotomized rat facial nuclei, identification and characterization in vitro.
Brain Res. 1989 Jul 17;492(1-2):1-14. doi: 10.1016/0006-8993(89)90883-4. PMID:
2752292.

141: Graeber Manuel B, Streit WJ, Kreutzberg GW. Axotomy of the rat facial nerve leads
to increased CR3 complement receptor expression by activated microglial cells. J
Neurosci Res. 1988 Sep;21(1):18-24. doi: 10.1002/jnr.490210104. PMID: 3216409.

142: Duke DC, Moran LB, Pearce RK, Graeber Manuel B. The medial and lateral substantia
nigra in Parkinson’s disease: mRNA profiles associated with higher brain tissue
vulnerability. Neurogenetics. 2007 Apr;8(2):83-94. doi:
10.1007/s10048-006-0077-6. Epub 2007 Jan 9. PMID: 17211632.

143: Kalaitzakis ME, Graeber Manuel B, Gentleman SM, Pearce RK. The dorsal motor
nucleus of the vagus is not an obligatory trigger site of Parkinson’s disease: a
critical analysis of alpha-synuclein staging. Neuropathol Appl Neurobiol. 2008
Jun;34(3):284-95. doi: 10.1111/j.1365-2990.2007.00923.x. Epub 2007 Dec 5. PMID:
18053026.

144: Harris JE, Nuttall RK, Elkington PT, Green JA, Horncastle DE, Graeber Manuel B,
Edwards DR, Friedland JS. Monocyte-astrocyte networks regulate matrix
metalloproteinase gene expression and secretion in central nervous system
tuberculosis in vitro and in vivo. J Immunol. 2007 Jan 15;178(2):1199-207. doi:
10.4049/jimmunol.178.2.1199. PMID: 17202385.

145: Flügel A, Bradl M, Kreutzberg GW, Graeber Manuel B. Transformation of donor-
derived bone marrow precursors into host microglia during autoimmune CNS
inflammation and during the retrograde response to axotomy. J Neurosci Res. 2001
Oct 1;66(1):74-82. doi: 10.1002/jnr.1198. PMID: 11599003.

146: Moran LB, Graeber Manuel B. Towards a pathway definition of Parkinson’s disease:
a complex disorder with links to cancer, diabetes and inflammation.
Neurogenetics. 2008 Feb;9(1):1-13. doi: 10.1007/s10048-007-0116-y. Epub 2008 Jan

  1. PMID: 18196299; PMCID: PMC2238789.

147: Egensperger R, Kösel S, Schnabel R, Mehraein P, Graeber Manuel B. Apolipoprotein
E genotype and neuropathological phenotype in two members of a German family
with chromosome 14-linked early onset Alzheimer’s disease. Acta Neuropathol.
1995;90(3):257-65. doi: 10.1007/BF00296509. PMID: 8525799.

148: Tran CT, Wolz P, Egensperger R, Kösel S, Imai Y, Bise K, Kohsaka S,
Mehraein P, Graeber Manuel B. Differential expression of MHC class II molecules by
microglia and neoplastic astroglia: relevance for the escape of astrocytoma
cells from immune surveillance. Neuropathol Appl Neurobiol. 1998
Aug;24(4):293-301. doi: 10.1046/j.1365-2990.1998.00120.x. PMID: 9775395.

149: Alafuzoff I, Pikkarainen M, Neumann M, Arzberger T, Al-Sarraj S, Bodi I,
Bogdanovic N, Bugiani O, Ferrer I, Gelpi E, Gentleman S, Giaccone G, Graeber Manuel B,
Hortobagyi T, Ince PG, Ironside JW, Kavantzas N, King A, Korkolopoulou P, Kovács
GG, Meyronet D, Monoranu C, Nilsson T, Parchi P, Patsouris E, Revesz T,
Roggendorf W, Rozemuller A, Seilhean D, Streichenberger N, Thal DR, Wharton SB,
Kretzschmar H. Erratum to: Neuropathological assessments of the pathology in
frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-
laboratory study by the BrainNet Europe consortium. J Neural Transm (Vienna).
2015 Jul;122(7):973-4. doi: 10.1007/s00702-014-1337-5. Erratum for: J Neural
Transm (Vienna). 2015 Jul;122(7):957-72. PMID: 25418279.

150: Tetzlaff W, Graeber Manuel B, Bisby MA, Kreutzberg GW. Increased glial fibrillary
acidic protein synthesis in astrocytes during retrograde reaction of the rat
facial nucleus. Glia. 1988;1(1):90-5. doi: 10.1002/glia.440010110. PMID:
2976741.

151: Kurz A, Egensperger R, Haupt M, Lautenschlager N, Romero B, Graeber Manuel B,
Müller U. Apolipoprotein E epsilon 4 allele, cognitive decline, and
deterioration of everyday performance in Alzheimer’s disease. Neurology. 1996
Aug;47(2):440-3. doi: 10.1212/wnl.47.2.440. PMID: 8757017.

152: Kösel S, Egensperger R, Bise K, Arbogast S, Mehraein P, Graeber Manuel B. Long-
lasting perivascular accumulation of major histocompatibility complex class II-
positive lipophages in the spinal cord of stroke patients: possible relevance
for the immune privilege of the brain. Acta Neuropathol. 1997 Dec;94(6):532-8.
doi: 10.1007/s004010050747. PMID: 9444354; PMCID: PMC7086531.

153: Streit WJ, Graeber Manuel B, Kreutzberg GW. Expression of Ia antigen on
perivascular and microglial cells after sublethal and lethal motor neuron
injury. Exp Neurol. 1989 Aug;105(2):115-26. doi: 10.1016/0014-4886(89)90111-8.
PMID: 2753113; PMCID: PMC7130334.

154: Streit WJ, Graeber Manuel B, Kreutzberg GW. Peripheral nerve lesion produces
increased levels of major histocompatibility complex antigens in the central
nervous system. J Neuroimmunol. 1989 Feb;21(2-3):117-23. doi:
10.1016/0165-5728(89)90167-7. PMID: 2913044; PMCID: PMC7119897.

155: Graeber Manuel B. Microglia, macrophages and the blood-brain barrier. Clin
Neuropathol. 1993 Sep-Oct;12(5):296-7. PMID: 8222403.

156: Schoen SW, Graeber Manuel B, Tóth L, Kreutzberg GW. Synaptic 5′-nucleotidase is
transient and indicative of climbing fiber plasticity during the postnatal
development of rat cerebellum. Brain Res Dev Brain Res. 1991 Jul
16;61(1):125-38. doi: 10.1016/0165-3806(91)90122-y. PMID: 1914153.

157: Kuecherer-Ehret A, Graeber Manuel B, Edgar D, Thoenen H, Kreutzberg GW.
Immunoelectron microscopic localization of laminin in normal and regenerating
mouse sciatic nerve. J Neurocytol. 1990 Feb;19(1):101-9. doi:
10.1007/BF01188442. PMID: 2351991.

158: Kösel S, Grasbon-Frodl EM, Arima K, Chimelli L, Hahn M, Hashizume Y,
Hulette C, Ikeda K, Jacobsen PF, Jones M, Kobayashi M, Love S, Mizutani T,
Rosemberg S, Sasaki A, Smith TW, Takahashi H, Vortmeyer AO, Graeber Manuel B. Inter-
laboratory comparison of DNA preservation in archival paraffin-embedded human
brain tissue from participating centres on four continents. Neurogenetics. 2001
Jul;3(3):163-70. doi: 10.1007/s100480100114. PMID: 11523568.

159: Graeber Manuel B, Bise K, Mehraein P. Synaptic stripping in the human facial
nucleus. Acta Neuropathol. 1993;86(2):179-81. doi: 10.1007/BF00334886. PMID:
8213072.

160: Korr H, Philippi V, Helg C, Schiefer J, Graeber Manuel B, Kreutzberg GW.
Unscheduled DNA synthesis and mitochondrial DNA synthetic rate following injury
of the facial nerve. Acta Neuropathol. 1997 Dec;94(6):557-66. doi:
10.1007/s004010050750. PMID: 9444357.

161: Kösel S, Lücking CB, Egensperger R, Graeber Manuel B. Nonradioactive PCR
sequencing using digoxigenin. Methods Mol Biol. 2003;226:347-54. doi:
10.1385/1-59259-384-4:347. PMID: 12958520.

162: Graeber Manuel B. Development of the microglia literature. Neuropathol Appl
Neurobiol. 1994 Apr;20(2):215-6. PMID: 8072671.

163: Kösel S, Lücking CB, Egensperger R, Graeber Manuel B. Nonradioactive PCR
sequencing using digoxigenin. Methods Mol Biol. 1996;65:81-9. doi:
10.1385/0-89603-344-9:81. PMID: 8956254.

164: Schoen SW, Graeber Manuel B, Kreutzberg GW. 5′-Nucleotidase immunoreactivity of
perineuronal microglia responding to rat facial nerve axotomy. Glia.
1992;6(4):314-7. doi: 10.1002/glia.440060410. PMID: 1464463.

165: Graeber Manuel B, Streit WJ, Kreutzberg GW. Formation of microglia-derived brain
macrophages is blocked by adriamycin. Acta Neuropathol. 1989;78(4):348-58. doi:
10.1007/BF00688171. PMID: 2782046.

166: Schoen SW, Graeber Manuel B, Reddington M, Kreutzberg GW. Light and electron
microscopical immunocytochemistry of 5′-nucleotidase in rat cerebellum.
Histochemistry. 1987;87(2):107-13. doi: 10.1007/BF00533394. PMID: 3040642.

167: Graeber Manuel B, Monaco AP, Chelly J, Müller U. Isolation of DNTR polymorphisms
from yeast artificial chromosomes encompassing X chromosomal loci PGK1 and
DXS56. Hum Genet. 1992 Nov;90(3):270-4. doi: 10.1007/BF00220077. PMID: 1339399.

168: Moran LB, Kösel S, Spitzer C, Schwaiger FW, Riess O, Kreutzberg GW, Graeber
MB. Expression of alpha-synuclein in non-apoptotic, slowly degenerating facial
motoneurones. J Neurocytol. 2001 Jun;30(6):515-21. doi: 10.1023/a:1015697318437.
PMID: 12037467.

169: Grasbon-Frodl EM, Kösel S, Riess O, Müller U, Mehraein P, Graeber Manuel B.
Analysis of mitochondrial targeting sequence and coding region polymorphisms of
the manganese superoxide dismutase gene in German Parkinson disease patients.
Biochem Biophys Res Commun. 1999 Feb 24;255(3):749-52. doi:
10.1006/bbrc.1998.9998. PMID: 10049782.

170: Graeber Manuel B, Kreutzberg GW. Astrocytes increase in glial fibrillary acidic
protein during retrograde changes of facial motor neurons. J Neurocytol. 1986
Jun;15(3):363-73. doi: 10.1007/BF01611438. PMID: 3746351.

171: Graeber Manuel B, Müller U, Monaco AP, Weber JL. Four dinucleotide repeat
polymorphisms at the D7S804 locus. Hum Mol Genet. 1993 Dec;2(12):2195. doi:
10.1093/hmg/2.12.2195. PMID: 8111392.

172: Schoen SW, Graeber Manuel B, Tóth L, Kreutzberg GW. 5′-Nucleotidase in postnatal
ontogeny of rat cerebellum: a marker for migrating nerve cells? Brain Res. 1988
Mar 1;467(1):125-36. doi: 10.1016/0165-3806(88)90074-0. PMID: 2834026.

173: Kösel S, Graeber Manuel B. Non-radioactive direct sequencing of PCR products
amplified from neuropathological specimens. Brain Pathol. 1993 Oct;3(4):421-4.
doi: 10.1111/j.1750-3639.1993.tb00770.x. PMID: 8293198.

174: Raivich G, Gehrmańn J, Graeber Manuel B, Kreutzberg GW. Quantitative
immunohistochemistry in the rat facial nucleus with [125I]-iodinated secondary
antibodies and in situ autoradiography: non-linear binding characteristics of
primary monoclonal and polyclonal antibodies. J Histochem Cytochem. 1993
Apr;41(4):579-92. doi: 10.1177/41.4.8450197. PMID: 8450197.

175: Graeber Manuel B, Lowe J, Radotra B. A free community approach to classifying
disease. PLoS Med. 2004 Nov;1(2):e16. doi: 10.1371/journal.pmed.0010016. Epub
2004 Nov 30. PMID: 15578101; PMCID: PMC529419.

176: Streit WJ, Graeber Manuel B. Perivascular location and phenotypic heterogeneity
of microglial cells in the rat brain. J Neuroimmunol. 1991 Jul;33(1):87. doi:
10.1016/0165-5728(91)90038-9. PMID: 2056072.

177: Graeber Manuel B. The role of astrocytes in facial nerve regeneration. Eur Arch
Otorhinolaryngol. 1994 Dec:S75-7. doi: 10.1007/978-3-642-85090-5_21. PMID:
10774318.

178: Graeber Manuel B, Banati RB, Streit WJ, Kreutzberg GW. Immunophenotypic
characterization of rat brain macrophages in culture. Neurosci Lett. 1989 Sep
11;103(3):241-6. doi: 10.1016/0304-3940(89)90106-7. PMID: 2682390.

179: Egensperger R, Herrmann H, Kösel S, Graeber Manuel B. Association between ACT
polymorphism and Alzheimer’s disease. Neurology. 1998 Feb;50(2):575-6. doi:
10.1212/wnl.50.2.575. PMID: 9484411.

180: Kurz A, Egensperger R, Lautenschlager N, Haupt M, Altland K, Graeber Manuel B,
Müller U. Das Apolipoprotein-E-Gen und der Phänotyp der Alzheimer-Krankheit [The
apolipoprotein E gene and Alzheimer disease phenotype]. Z Gerontol Geriatr. 1995
May-Jun;28(3):195-9. German. PMID: 7664194.

181: Raivich G, Hellweg R, Graeber Manuel B, Kreutzberg GW. The expression of growth
factor receptors during nerve regeneration. Restor Neurol Neurosci. 1990 Jan
1;1(3):217-23. doi: 10.3233/RNN-1990-13407. PMID: 21551559.